Ipsen: Iqirvo normalizes ALP in 85.3% of Phase III patients, versus 23.3% on placebo
In a press release published on November 5, 2026, Ipsen unveiled the results of the Phase III ELSPIRE study, conducted in primary biliary cholangitis (PBC). The company presents the data as ones that “raise the bar” in this disease, and states that its treatment was “generally well tolerated”.
Patients selected by ALP level, compared with placebo
The ELSPIRE study involved people with PBC whose alkaline phosphatase (ALP) level was between 1 and 1.67 times the upper limit of normal. The company describes ALP as a biochemical measure of disease activity.
At week 52, normalization of this marker was achieved by 85.3% of patients treated with Iqirvo. In the placebo arm, this proportion was 23.3%.
A publication in Hepatology and a therapeutic goal highlighted
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The results will be presented among the late-breaking data at The Liver Meeting 2026. They will be published simultaneously in Hepatology, the flagship journal of the AASLD.
For Ipsen, these results “add to a growing body of evidence supporting ALP normalization as an achievable therapeutic goal in PBC”.
SectorPharmacie et biotechnologies›Pharmacie, vaccins et santé animale
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Context
Period
Period: T3 2026
Key reported figures
Revenue: 1 174 millions d'euros
Quarterly revenue: 1 174 millions d'euros
Revenue growth: 28,3 %
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